Yintoni iGout? Yintoni elungele iGout?

Yintoni iGout? Yintoni elungele iGout?
I-Gout, eyaziwa ngokuba sisifo sookumkani okanye isifo sezityebi, sisifo esibi kakhulu se-rheumatic esikhokelela ekufeni kweesultan.

I-Gout , eyaziwa ngokuba sisifo sookumkani okanye isifo sezityebi, sisifo esibi kakhulu se-rheumatic esakhokelela ekufeni kwama-sultan. Nangona igawuthi, ekwabizwa ngokuba sisifo segawuthi, ikudidi lwezifo zamathambo, inokuthathwa njengesifo semetabolism. Esi sifo, esixhaphake kakhulu emadodeni, sinokuchaphazela kakubi umsebenzi womntu kunye nobomi bentlalontle.

IGout ligama elisetyenziselwa ukubhekisa kwiimeko ezahlukeneyo eziphawulwa kukufumba kwe-uric acid. Oku kufumba kudla ngokubakho ezinyaweni zomntu. Abantu abanegawuthi banokuva ukudumba kunye neentlungu kumalungu onyawo. Ubhontsi omkhulu ngomnye wamalungu achaphazeleka kakhulu sesi sifo. Uhlaselo lwegawuthi lubangela iintlungu ezikhawulezileyo nezibukhali kwaye abantu banokuziva ngathi iinyawo zabo ziyatshisa. Nangona iimpawu zegawuthi zezokwexeshana, kukho iindlela ezahlukeneyo zokulawula iimpawu.

Yintoni iGout?

I-Gout, i-chronic (ixesha elide) kunye nokuvuvukala okuhlangeneyo okuqhelekileyo, yintlupheko ebonakaliswe ngokuqokelelwa kwe-crystals ye-monohydrate ebizwa ngokuba yi-monosodium urate kwizicubu. I-Gout, imbali yayo ibuyele kumaxesha amandulo, isifo se-rheumatological esiye safundwa ngokubanzi kwaye sinokulawulwa.

Phantsi kweemeko eziqhelekileyo, inkunkuma ekhoyo emzimbeni, ngakumbi inkunkuma yeprotheyini, iguqulwa ibe yi-uric acid kwaye isuswe emzimbeni. Iingxaki ekukhupheni i-uric acid okanye ukuvelisa kakhulu kwezi zinto kunokubangela ukuqokelelana egazini nasemzimbeni. Xa isixa se-uric acid egazini singaphezulu kwesiqhelo, loo nto ibizwa ngokuba yi-hyperuricemia. Le meko inokuqhubela phambili kwi-gaut ekuhambeni kwexesha kwaye ibangele ukudumba kwamalungu abuhlungu kakhulu.

I-Hyperuricemia ikwabangela ukuba umchamo kunye negazi libe ne-asidi ephezulu. Ezinye iinyama, iziselo ezinxilisayo ezifana nebhiya, iigeraniums kunye neembotyi ezomisiweyo ziphakathi kokutya okune-uric acid ephezulu. Ngaphandle kokutya, imiba yemfuza, ukutyeba ngokugqithiseleyo okanye ukutyeba ngokugqithiseleyo, noxinezeleko zezinye zezinto ezayanyaniswa nokonyuka kwamanqanaba euric acid egazini.

I-Uric acid, efumaneka kwizixa ezigqithisileyo egazini, ivuza kwizithuba zeethishu kwaye iqokelelane kumalungu kunye nezakhiwo ezingqongileyo. Ukuqokelela kumalungu kunokubangela ukuvuvukala kwezi ndawo, okukhokelela ekunyuseni kwamanzi kumalungu, izithintelo zokuhamba kunye neentlungu. Esi sifo, esichaphazela ngokukodwa uzwane olukhulu kunye namalungu amadolo, sibizwa ngokuba yigout. Ngamanye amaxesha i-uric acid inokuthi iqokelele kwizintso. Unonophelo kufuneka luthathwe njengoko oku kunokubangela ukwakheka kwamatye kwizintso.

Ngawaphi amanqanaba eSifo seGout?

Isifo se-Gout siqhubela phambili kwizigaba ezi-4: ukuhlaselwa ngokukhawuleza, ixesha eliphakathi, i-gout engapheliyo kunye ne-tophus gout.

  • Uhlaselo oluqatha: Sisigaba sesifo esiqala ngokukhawuleza kwindibaniselwano kwaye sithatha iintsuku ezi-5-10. Ukuvuvukala kwexesha elifutshane kunye neentlungu zibonwa kumalungu.

  • I-Intercritical Period: Eli linqanaba apho izikhalazo zesigulane ziphela ngokupheleleyo. Nangona kunjalo, uhlaselo oluqatha lunokuthi lwenzeke kwakhona ngokukhawuleza emva kwesi sigaba.
  • I-Gout engapheliyo: Ukuba ixesha eliphakathi kokuhlaselwa linciphisa kancinci kwaye lingaphathwa, ukuvuvukala okusisigxina, intlungu kunye nokunciphisa ukunyakaza kunokwenzeka kwilungu elinye okanye ngaphezulu.
  • I-Tophus Gout: Njengoko isifo siqhubela phambili, i-uric acid iqokelela ngokugqithisileyo kumalungu kunye nezicubu ezingqongileyo kwaye zenze ukudumba okubizwa ngokuba yi-tophi. I-Tophi yenzeka ngakumbi kuzwane omkhulu, ithambo le-metatarsal, ngaphezulu kweminwe nakufuphi neengqiniba.

Ziziphi iimpawu zesifo segawuthi?

Ngenxa yokuqokelela i-asidi ion emzimbeni ekuseni, ukuvuvukala kwenzeka kumalungu kunye neentlungu ezinzima. Enyanisweni, intlungu inzima kangangokuba isigulane sivuka ebuthongweni. I-Gout sisifo esibangelwa kukuqokelelana kwe-uric acid kwizintso Ukongeza kwiimpawu ezifana negazi kumchamo kunye namatye, iintlungu zesisu kunye nomqolo zinokubakho. Iintlungu ziba ezingapheliyo kunye ne-uric acid eqokelelwe kumalungu inokubangela ukudumba rhoqo kwamalungu kwaye kubangele ukuguquka.

I-Gout ngokuqhelekileyo ithathwa njengokuvuvukala kwamalungu (arthritis). Ukuqala kokuhlaselwa ngokukhawuleza kwaye kubuhlungu. Iimpawu ezahlukeneyo zinokuthi zenzeke kwindawo edibeneyo echaphazelekayo, kubandakanywa ukutshisa, ukuqina, kunye nokuvuvukala. Iimpawu zegawuthi zinokwahluka kumntu nomntu. Isenokude ilandele ikhosi ye-asymptomatic kwabanye abantu. Ngelixa aba bantu befunyaniswa benyusile amanqanaba euric acid egazini, akukho sikhalazo malunga negawuthi. Iimpawu ezenzeka ngexesha lokuhlaselwa zibizwa ngokuba yi-acute gout iimpawu. Ubuhlungu, ubomvu kunye ne-edema yimpawu eziphambili zokuhlaselwa kwe-gout. Ngokukodwa emva kohlaselo oluqala ebusuku, abantu banokuvuka ebuthongweni ngenxa yeempawu. Nokuba unxibelelwano oluncinci kakhulu kwindawo echaphazelekayo lunokubangela izikhalazo ezinganyamezelekiyo. Ngexesha elifanayo, kukho umda kwiintshukumo zomgudu ochaphazelekayo.

Izikhalazo ezenzeka kuhlaselo oluqatha lwegout zidla ngokuvela kwindawo enye. Inzwane enkulu yeyona ndawo ixhaphakileyo edibeneyo. Nangona ubude bezikhalazo buhlala buhluka phakathi kweeyure ze-12-24, kukho iimeko ezinzima ze-gout apho iimpawu ziqhubeka iintsuku ezili-10. Izigulane ziqhubeka nobomi babo ngaphandle kwezikhalazo ngexesha eliphakathi kokuhlaselwa kwe-gout.

Ukuhlaselwa rhoqo kwe-gout ebukhali kunokubangela umonakalo osisigxina kumalungu. Ukongeza kwintlungu edibeneyo, iimpawu ezinjengokuvuvukala, ubomvu, i-edema kunye neengxaki zokuhamba ziphucula ngokuhamba kwexesha, ngelixa iimpawu ezifana nokuxubha kunye nokubetha kwesikhumba sommandla ochaphazelekayo zingenzeka. Kwesi sifo, esinokuthi sichaphazele amanye amalungu omzimba ngaphandle kozwane olukhulu, amalungu esihlahla, iminwe, ingqiniba, isithende kunye nomphezulu wonyawo ziphakathi kwezinye iindawo ezinokuchatshazelwa yigawuthi.

Ukuba uhlaselo lwegawuthi lwenzeka rhoqo kunesiqhelo, oku kubizwa ngokuba sisifo segawuthi esingapheliyo. Ukunyamekela kufuneka kuthathwe njengoko uhlaselo lwegawuthi olungapheliyo lunokukhokelela kwiingxaki ezinzulu zempilo ukuba aluphathwanga ngokufanelekileyo. Kwizigulane ze-gout ezingapheliyo, intlungu ingaba yinto eqhubekayo, kwaye kule meko, umgangatho wokulala womntu uchaphazeleka kakubi. Iingxaki ezinjengokukhathala, ukwanda koxinzelelo kunye nokutshintsha kwemizwelo kunokuthi kwenzeke ngenxa yokuphuthelwa. Ngaphandle komgangatho wokulala, ukuhamba, ukwenza umsebenzi wasekhaya, kunye neminye imisebenzi eqhelekileyo yemihla ngemihla nako kunokuchaphazeleka kakubi.

I-Tophi sisikhalazo segawuthi esingapheliyo esibonakaliswa kukuqokelelana kweekristale ze-uric acid phantsi kwesikhumba. I-Tophus, enokuthi yenzeke ezandleni, ezinyaweni, ezihlahleni nasezindlebeni, ibonakala njengokudumba okuqinileyo kwe-subcutaneous okungekho buhlungu kodwa ukudumba kunye ne-edema ngexesha lohlaselo. Njengoko i-tophus iqhubeka ikhula, inokonakalisa ulusu olujikelezileyo kunye nezicubu ezidibeneyo. Kubaluleke kakhulu ukufumana unyango olufanelekileyo njengoko ukukhubazeka kwamalungu kunokwenzeka njengoko le meko iqhubela phambili.

I-Uric acid, efumaneka kwizixa eziphezulu egazini, inokuqokelelana emiphungeni nakwizintso. Ngaphandle kwale meko inqabileyo kakhulu, kucetyiswa ukuba uqaphele njengoko iingxaki zempilo ezahlukeneyo ezifana ne-cataracts kunye ne-syndrome yamehlo eyomileyo inokuthi yenzeke kwizigulane ze-gout ezingapheliyo.

Yintoni Ebangela IGout?

Oyena nobangela ubalulekileyo wegawuthi kukuvelisa ngokugqithisileyo komzimba uric acid okanye ukungakwazi ukukhupha iuric acid eveliswayo kwizintso. Ukutya ngendlela engafanelekanga, ukusela utywala ngokugqithisileyo, izifo zequbuliso nezimandundu, unyango lweziyobisi olwahlukeneyo, ukungcungcutheka kwamalungu, utyando kunye nezifo zezintso zezinye zeemeko ezinokubangela ukwanda komthamo we-uric acid egazini. Ukukhula ngeminyaka nako kunokunyusa umngcipheko wokuba negawuthi. Igawuthi sisifo esisenokubakho kwiintsapho kwabanye abantu. Ubuninzi bejini ezahlukeneyo, ngakumbi i-SLC2A9 kunye ne-ABCG2 yofuzo, inokukhokelela kwigawuthi. Iimfuza ezinxulumene negawuthi zinxulunyaniswa ne-uric acid metabolism.

Kuyavunywa ukuba izinto zofuzo zinokuthi zisebenze ekubunjweni kwe-gout, kwaye ngaphezu kwezinto zentsapho, ezinye izifo zinokuba nefuthe lokuququzelela. Ukutyeba ngokugqithiseleyo, isifo seswekile, isifo sentliziyo, uxinzelelo lwegazi oluphezulu kunye necholesterol ephezulu zezinye zezifo apho umngcipheko wokuba negawuthi uphezulu kwizigulana.

Ngexesha lokuphazamiseka okuthile, ukwanda kwemveliso ye-uric acid emzimbeni kunokwenzeka. Le meko, ehambelana nemisebenzi ye-enzyme engaqhelekanga, ngokuqhelekileyo ivela kwiimeko ezifana ne-lymphoma, i-leukemia, i-hemolytic anemia kunye ne-psoriasis. Ukwanda kwemveliso ye-uric acid kungenzeka njengesiphumo esisecaleni emva kwechemotherapy kunye neradiotherapy esetyenziswa kunyango lwezigulane ezinomhlaza.

Sifunyaniswa njani isifo seGout?

Ukufunyanwa kweekristale ze-monosodium urate kwi-synovial fluid (ulwelo kwindawo edibeneyo) uhlalutyo yindlela esemgangathweni yegolide yokuxilongwa kwegawuthi. Kolu vavanyo, oogqirha bathatha isampuli yamanzi ukusuka kwindawo edibeneyo echaphazelekayo kunye nenaliti encinci. I-Synovial fluid iba tyheli kwaye ibe namafu ngexesha lokugqabhuka kwegout. Ukuhlolwa kweMicroscopic kolu lwelo, olukwaqulethe iikristale kunye neeseli ezimhlophe zegazi, kuyahlula ekudumbeni kwamalungu okubangelwa yimichiza emincinci.

Uphononongo olwahlukeneyo lwaselabhoratri lunokusetyenziswa kwakhona kwindlela yokuxilonga kwigawuthi. Nangona iimpawu ze-biochemical ezifana nokubala kweeseli ezimhlophe zegazi, izinga le-erythrocyte sedimentation (ESR) kunye ne-protein ye-c-reactive (CRP) ziluncedo kwi-gout ebukhali, akufanele ilibaleke ukuba azikho ngqo kwesi sifo. Nangona ukulinganisa inqanaba le-uric acid ngovavanyo lwegazi kuluvavanyo olubaluleke kakhulu, ngamanye amaxesha kunokukhokelela ekulahlekeni. Kufuneka kukhunjulwe ukuba ngelixa abanye abantu benamanqanaba aphezulu e-uric acid egazini kodwa bengenazo iimpawu zegawuthi, abanye abantu banokuba neempawu zegawuthi nangona amanqanaba e-uric acid egazini labo esezantsi. Ngenxa yezi zizathu, nangona umlinganiselo wegazi le-uric acid uwodwa ungajongwa njengowaneleyo ukuxilongwa kwegawuthi, unokusetyenziselwa ukuvavanya ikhosi yegawuthi kwezinye izigulana.

Ukongeza kwiimvavanyo ze-biochemical, izifundo ezahlukeneyo zokucinga zingasetyenziselwa ukuxilonga i-gout. Nangona ingenziwanga ngokuqhelekileyo, i-ultrasonography inokubona iikristale eziqokelelwe kwindawo ye-cartilage. Iiradiographs zeX-reyi ziphakathi kwezixhobo zokuxilonga ngemitha ezinokuba luncedo ekwahluleni igawuthi kwezinye izigulo zamalungu.

Sinyangwa njani isifo seGout?

Kwi-gout, iindlela zonyango ezihlukeneyo zisetyenziswa ngexesha lokuhlaselwa ngokukhawuleza kunye namaxesha phakathi kokuhlaselwa. Ngelixa izidakamizwa ezichasayo zisetyenziswa ngamaxesha anzima xa intlungu inzima, iziyobisi ezisetyenziselwa unyango lweziyobisi zingatshintshwa ngoogqirha ngokuxhomekeke kwikhosi yesifo. Iziyobisi ezingekho steroidal ezichasene nokudumba, icolchicine okanye i-corticosteroids ziphakathi kwamachiza anokusetyenziswa kunyango lwegawuthi, kuxhomekeke kwimeko yomntu. Amayeza aqulethe isithako esisebenzayo i-colchicine ngamachiza achasene nokudumba abonwa esebenzayo ekulawuleni iintlungu ezibangelwa yigawuthi.

Kwezinye izigulane, i-gout flares ingaba nekhosi enzima kakhulu kwaye engapheliyo. Ukuze kuthintelwe amatye entso, i-tophus okanye ezinye iingxaki ezinxulumene ne-gout ezinokuthi zenzeke kwaba bantu, amayeza anciphisa ukuveliswa kwe-uric acid emzimbeni okanye ukwandisa uric acid excretion kumchamo angasetyenziswa. Kubaluleke kakhulu ukuba ukusetyenziswa kwezi ziyobisi, ezinokubangela iziphumo ebezingalindelekanga ezifana nomkhuhlane, irhashalala, ukudumba kwesibindi okanye iingxaki zezintso, kuqhutywe phantsi kweliso likagqirha.

Ekubeni umsebenzi womzimba unokwandisa ubunzima bokuhlaselwa, izigulane zinconywa ukuba ziphumle ngexesha elinzima. Unyango lokutya ludlala indima ebalulekileyo njengamayeza kwi-gout. Ukunyangwa kwe-gout, izigulane zicetyiswa ukuba zilandele ukutya okukhethekileyo okulungiselelwe yi-dietician, zidle amanzi amaninzi kunye nokuphucula umgangatho wobomi kunye neenkqubo zokuzilolonga ezilula.

Ukutya kwezifo zeGout

Ukulungiselela inkqubo yesondlo somntu ngamnye efanele igawuthi lelinye lawona manyathelo abalulekileyo anokuthi athathwe ukunciphisa inani lokunyuka. Oku kutya kujolise ekunciphiseni izinga le-uric acid egazini kwimida eqhelekileyo.

Ukukhawulela okanye ukunqanda ngokupheleleyo ukusela utywala, ngakumbi ukusetyenziswa kwebhiya, lutshintsho olubalulekileyo lwendlela yokuphila ekuphuculeni iimpawu zegawuthi. Ukongeza, ukwandisa ukusetyenziswa kwamanzi, ukukhetha iimveliso zobisi ezinamafutha aphantsi, ukuphepha ukusetyenziswa kwenyama yenyama okanye intlanzi encinci enamafutha kunye ne-purine ephezulu, ukukhetha i-legumes njengomthombo weprotheni, kunye nokutya iimveliso zengqolowa okanye imifuno emitsha kunye neziqhamo zokusetyenziswa kwe-carbohydrate zifakiwe. kwisicwangciso sokutya Kuphakathi kwezinye izicelo ezinokwenzeka.

Ukutya okunomxholo ophantsi we-purine ekutyeni kuchazwa njengokutya okuqukethe ngaphantsi kwe-100 milligrams ye-purine nge-100 grams. Zonke iziqhamo ziphakathi kokutya okungekho ngxaki kwigawuthi. I-Cherry fruit inokuxhasa imisebenzi eqhelekileyo yomzimba ekuthinteleni uhlaselo lwegawuthi ngenxa yegalelo layo kumanqanaba e-uric acid kunye namanqanaba okudumba. Zonke iimveliso zemifuno, kubandakanywa amazambane, ii-peas, amakhowa, ii-eggplants kunye nemifuno eluhlaza eluhlaza, ziphakathi kokutya okunokuthi kusetyenziswe izigulane ze-gout. Ukongeza kwiziqhamo kunye nemifuno, amaqanda, iimveliso zobisi, i-nut, ikhofi, itiye kunye ne-green tea, iziqholo kunye namafutha emifuno kukutya okunokufakwa kwisicwangciso sesondlo sezigulane ze-gout.

Ukunciphisa Ubunzima Bomzimba

Ubunzima obugqithisileyo bunokuba ngumngcipheko wokuhlaselwa kwegout. Ukumelana ne-insulin, okwenzeka ngokukodwa kubantu abatyebe kakhulu, yimeko ethathwa njengeyanyaniswa namanqanaba aphezulu e-uric acid egazini. Ngokuncipha kobunzima, abantu banokophula bobabini ukumelana nehomoni ye-insulin kwaye bafake isandla ekunciphiseni amanqanaba e-uric acid.

Into yokuba izigulane ze-gout kufuneka zihlawule ingqalelo xa kuziwa ekulahlekeni kwesisindo kukukhawuleza kokunciphisa umzimba. Ukunyamekela kufuneka kuthathwe njengoko ukulahleka kwesisindo ngokukhawuleza kwisidlo esisezantsi kakhulu kunokunyusa umngcipheko wokuhlaselwa kwegout.

Ukwenza umthambo

Ukuzilolonga rhoqo lolunye uqheliselo olunokwenziwa ukuze kuthintelwe uhlaselo lwegawuthi yaye kunokuba negalelo ekwehliseni umlinganiselo weuric acid.

Ukusetyenziswa okwaneleyo kolwelo

Ukuqinisekisa ukusetyenziswa okwaneleyo kolwelo lwemihla ngemihla kunokunciphisa umngcipheko wokuhlaselwa yigout. Ngokuthatha ulwelo, ukukhutshelwa kwe-uric acid eyongezelelweyo kwigazi eliphuma kwizintso kuba lula kwaye kususwa ngomchamo. Ukusetyenziswa kolwelo ngumba ekungafanelanga ukuba ungahoywa, ngakumbi ngabantu abenza umthambo rhoqo, abathi baphulukane nolwelo oluthile lomzimba ngenxa yokubila.

Ukunciphisa Ukusetyenziswa kotywala

Utywala yinto eyaziwayo ebangela igawuthi. Isizathu sale meko kukuba umzimba ubeka phambili ukukhutshelwa kotywala kunokususa uric acid egqithisileyo emzimbeni ngokusela utywala. Ngaloo ndlela, kuba lula kwi-uric acid, ehlala kwixabiso eliphezulu emva kokusetyenziswa kotywala, ukuqokelela kunye nokujika kwi-crystal form.

Ukutya, ukuzivocavoca kunye nolunye utshintsho lwendlela yokuphila lusebenza kakhulu ekunyangeni i-gout kunye nezinye iimeko zempilo ezibangelwa yi-uric acid ephezulu. Kwabanye abantu, unyango lwezonyango lunokuba yimfuneko ngaphezu kokutshintsha kwendlela yokuphila. Ukubambelela ngokungqongqo kumayeza amiselweyo ngoogqirha yinxalenye ebalulekileyo yonyango.

Ukuba uqaphela iimpawu ze-gout, eziluhlobo oluthile lokuvuvukala okuhlangeneyo, kuwe okanye abo bakujikelezile, kucetyiswa ukuba uqhagamshelane namaziko ononophelo lwezempilo kwaye ufumane uncedo koogqirha beengcali malunga nonyango olufanelekileyo kunye nokutshintsha kwendlela yokuphila.

Sikunqwenelela iintsuku ezisempilweni.